March 2, 2017 Clinical Trials

Clinical trials for Neurological Conditions

Clinical trials are essential to determine whether new drugs, diagnostics or procedures in the laboratory are both safe and effective when used to diagnose or treat people.Our office is recruiting patients for following clinical trials. Please remember that we do not bill for these studies to the insurance company, so it does not matter whether the patient is insured or not insured.

  1. Osteoarthritis of Hip or Knee
  2. Chronic Low back pain
  3. Moderate Alzheimer’s disease: MMSE 10-20 Pt on Namenda and Aricept.
  4. Any memory impairment, for Amyloid PET scan Evaluation (Medicare patients only)
  5. Complex partial/ Focal Epilepsy- Open label study
  6. Moderate advanced Parkinson’s disease
  7. Acute Migraine
  8. Chronic Migraine
  9. Agitation in Alzheimer’s disease
  10. Mild Alzheimer’s disease- Day Break study
  11. Stem cell treatment for stroke- chronic deficit
  12. Psychosis in Parkinson’s disease

Carefully conducted clinical trials are performed in human volunteers to provide answers to questions such as:
– Does a treatment work?
– Does it work better than other treatments?
– Does it have side effects?

If you would like to learn more about the clinical trial process, please visit our Research page.

Patient Safety:

We collaborate with regulatory agencies, monitor reports of adverse events experienced by patients and communicate on our product safety activities, as appropriate to the audience. Any medicine may cause side effects in some patients. Our priority is to make sure that the therapeutic benefits of the medicine outweigh the risks


November 3, 2016 Clinical Trials

Our office is recruiting patients for the following clinical trials:

  1. Osteoarthritis of Hip or Knee
  2. Chronic Low Back Pain
  3. Moderate Alzheimer’s disease MMSE 10-20 Pt on Nameda and Aricept
  4. Any memory impairment, for Amyloid PET Scan Evaluation (Medicare patients only)
  5. Epilepsy – Open label study
  6. Cluster Seizures
  7. Acute Migraine
  8. Chronic Migraine
  9. Agitation in Alzheimer’s disease
  10. Mild Alzheimer’s Day break study

You can learn more about the clinical trial process here:

If you have any questions, please contact:


August 20, 2016 Brain

Alzheimer’s disease (AD) is an irreversible, progressive disorder in which brain cells (neurons) deteriorate, resulting in the loss of cognitive functions, primarily memory, judgment and reasoning, movement coordination and pattern recognition. In advanced stages of the disease, all memory and mental functioning may be lost. The condition predominantly affects the cerebral cortex and hippocampus, which lose mass and shrink (atrophy) as the disease advances.

Brain Anatomy

The cerebral cortex is an extremely convoluted and complicated structure associated with the “higher” functions of the mind—thought, reasoning, sensation, and motion. Each hemisphere of the cerebral cortex contains areas that control certain types of activity. These areas are referred to as the frontal lobe, parietal lobe, temporal lobe, and occipital lobe.

  • The frontal lobe, located behind the forehead, is involved with controlling responses to input from the rest of the central nervous system (brain and spinal cord). It is responsible for voluntary movement, emotion, planning and execution of behavior, intellect, memory, speech, and writing.
  • The parietal lobe, located above the ear, receives and interprets sensations of pain pressure, temperature, touch, size, shape, and body part awareness.
  • The temporal lobe, located behind the ear, is involved in understanding sounds and spoken words, as well as emotion and memory.
  • The occipital lobe, located at the back of the head, is involved in understanding visual images and the meaning of the written word.

The hippocampus plays a crucial role in learning and in processing various forms of information as long-term memory. Damage to the hippocampus produces global amnesia.

Plaques and Tangles

The two most significant physical findings in the cells of brains affected by Alzheimer’s disease are neuritic plaques and neurofibrillary tangles. Another significant factor in AD is the greatly reduced presence of acetylcholine in the cerebral cortex. Acetylcholine is necessary for cognitive function.

While some neuritic plaques, or patches, are commonly found in brains of elderly people, they appear in excessive numbers in the cerebral cortex of Alzheimer’s disease patients. A protein called beta amyloid occupies the center of these plaques. Surrounding the protein are fragments of deteriorating neurons, especially those that produce acetylcholine (ACh), a neurotransmitter essential for processing memory and learning. Neurotransmitters are chemicals that transport information or signals between neurons. Neurofibrillary tangles (NFTs) are twisted remnants of a protein called tau, which is found inside brain cells and is essential for maintaining proper cell structure and function. An abnormality in the tau protein disrupts normal cell activity.

Incidence and Prevalence of Alzheimer’s Disease

According to the Alzheimer’s Association, about 5.2 million people in the United States suffer from Alzheimer’s disease—and two-thirds of those affected are women. The Association reports that about 3.2 million American women and 1.8 million American men over the age of 60 have Alzheimer’s. Approximately 10 percent of all people over the age of 65 and as many as 50 percent of those over the age of 85 are diagnosed with the condition, which is the sixth leading cause for death in the United States.


August 20, 2016 Brain

Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig’s disease, is a progressive neuromuscular disease that weakens and eventually destroys motor neurons (components of the nervous system that connect the brain with the skeletal muscles).

Upper motor neurons are located in the cerebral cortex of the brain and conduct impulses from the motor cortex to nerves in the brain or the spinal cord. Lower motor neurons are peripheral neurons that originate in the spinal cord and conduct impulses to the skeletal muscles. Skeletal muscles are involved with voluntary movements, such as walking and talking. The lower motor neurons transmit the command to move from the brain to the skeletal muscles, which respond by contracting.

A person with ALS usually presents with problems in dexterity or gait resulting from muscle weakness, or with difficulty speaking or swallowing. Sphincter control, sensory function, intellectual ability, and skin integrity are preserved. Patients become paralyzed and often require ventilation and surgery to provide a new opening in the stomach (gastrostomy). Loss of respiratory function is ultimately the cause of death for people who have ALS.

Incidence and Prevalence of ALS:

Approximately 30,000 patients in the United States currently have ALS. The disease has no racial, socioeconomic, or ethnic boundaries. The life expectancy of ALS patients usually ranges from about 3 to 5 years after diagnosis. ALS is most commonly diagnosed in middle age and affects men more often than women.


August 20, 2016 Brain

Attention-deficit hyperactivity disorder (ADHD) is a psychiatric disorder and, more specifically, a chronic neurobehavioral syndrome. ADHD manifests as inattention, impulsivity, and hyperactivity. The term attention-deficit disorder (ADD) refers to the condition without hyperactivity.

People with ADHD tend to overlook details and to miss information. Because of attention deficit, people with ADHD become averse to tasks that require concentration, decisiveness, and organizational skills and may avoid situations where they are expected to perform or to take responsibility for their effort.

Incidence and Prevalence of ADHD:

According to the Centers for Disease Control and Prevention (CDC), 6.4 million people between the ages of 4 and 17—11 percent of the population—in the United States were diagnosed with ADHD as of 2011. The CDC reports that 7.8 percent had an ADHD in 2003, 9.5 percent in 2007, and 11 percent in 2011—indicating about a 5 percent increase in each of those years.

The average age of diagnosis is 7 years. It’s estimated that about 2–4 percent of adults in the United States are affected. The occurrence of ADHD is reported worldwide; statistical variations may be due to cultural perceptions of behavior.

Most studies show that in children with ADHD, boys are affected approximately five times more often than girls. Other studies suggest that the condition may not be diagnosed as often in girls because girls with ADHD present their symptoms differently.


August 20, 2016 Spine

Neck and back pain, especially pain in the lower back, is one of the most common health problems in adults. In fact, according to the National Institute of Neurological Disorders and Stroke (NINDS) in 2014, lower back pain is the leading cause of disability worldwide. Fortunately, most back and neck pain is temporary, resulting from short-term stress on the muscles or ligaments that support the spine rather than from a serious injury or medical condition such as nerve damage or kidney disease.

According to our sister publication Remedy’s Healthy Living Spring 2013, in the largest study ever conducted in the United States about the benefits of yoga, researchers discovered that taking yoga classes or performing stretching exercises at least three times a week for 12 weeks helped ease moderate back pain symptoms. Participants in the study also were able to stay active and required less pain medication for at least six months after getting with the program. Talk to your health care provider before beginning an exercise program.

Back Anatomy

The back is an intricate structure of bones, ligaments, muscles, nerves, and tendons. The backbone, or spine, is made up of 33 bony segments called vertebrae:

  • 7 cervical (neck) vertebrae
  • 12 thoracic (middle back) vertebrae
  • 5 lumbar (lower back) vertebrae
  • 5 sacral (lowest area of the back) vertebrae
  • 4 coccygeal (coccyx, or tailbone) vertebra (made up of several fused segments)

The vertebrae are arranged in a long vertical column and held together by ligaments, which are attached to muscles by tendons. Between each vertebra lies a gel-like cushion called an intervertebral disc, consisting of semifluid matter (nucleus pulposus) that is surrounded by a capsule of elastic fibers (annulus fibrosus).

The spinal cord is an extension of the brain that runs through a long, hollow canal in the column of vertebrae. The meninges, cerebrospinal fluid, fat, and a network of veins and arteries surround, nourish, and protect the spinal cord.

Thirty-one pairs of nerve roots emerge from the spinal cord through spaces in each vertebra. The spinal cord and peripheral nerves perform essential sensory and motor activities of the body. The peripheral nervous system conveys sensory information from the body to the brain and conveys motor signals from the brain to the body.

Incidence and Prevalence of Back Pain

In the United States, back pain is reported to occur at least once in 85 percent of adults below the age of 50 and nearly all of them will have at least one recurrence. Back pain is the second most common illness-related reason given for a missed workday and the most common cause of disability. Work-related back injury is the number one occupational hazard.

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