Does your loved one with Alzheimer’s disease believe things that are not true?

Alzheimer’s disease (AD) affects memory, ability to think, and social skills. People with AD may also have psychosis. This is called Alzheimer’s disease psychosis (ADP). It involves hallucinations and delusions. Hallucinations include hearing or seeing things that others do not. Delusions include believing things that are not true. A person with ADP may have thoughts that:

• people are plotting against them
• their possessions are being stolen
• images on the television are real
• the person in the mirror is someone else.

The Radiant Study is looking at a potential new drug (study drug) to see how effective and safe it is at reducing delusions and hallucinations associated with ADP.

People taking part in this study must have a designated care partner who can attend all study center visits with them.

About 1000 people from around the world will take part in the Radiant Study. The study will compare the effects of the study drug to a placebo. A placebo looks like the study drug but contains no active medicine. A placebo helps to see if any effects of the study drug are due to people’s expectations of whether it may work or not. The placebo and study drug together are called the study medication.

People taking part in this study will be randomly assigned to 1 of 3 groups:

• 2 groups will receive the study drug
• 1 group will receive placebo

You have an equal chance of being in any group.

At the end of the study, you may be able to take part in what is known as an open-label extension (OLE) study. In the OLE study, everyone will receive the study drug.

What to expect?

The Radiant Study will last for about 4 months. People taking part in the study will need to visit the study center about 6 times. There will also be times when the person in the study or their care partner will need to speak by phone to the study team.

People in the study will have several tests and assessments performed to monitor their health. These will include:

• Questionnaires and interviews about how they feel, how they are sleeping, and how AD affects their daily life
• Physical and neurological examinations
• Measurements of vital signs (for example: blood pressure, heart rate, breathing rate, and temperature)
• Urine and blood samples

Who can take part?

To possibly be able to take part, a person must:

• be 55–95 years of age
• live at home, in a nursing home, or an assisted-living facility
• have probable AD with symptoms of psychosis
• have a designated care partner who can attend all study center visits with them.

The study team will explain the possible benefits and risks of taking part. If you need additional information, please reach out to our research team.